The metabolism of 3-hydroxyanthranilic and quinolinic acids in the chick embryo.
نویسندگان
چکیده
منابع مشابه
Niacin biosynthesis in the developing chick embryo.
In 1945, Krehl et al. (1) observed that tryptophan and nicotinic acid were mutually interchangeable, within limits, in supporting the growth of rats. Since that time considerable evidence has accumulated which demonstrates the biosynthesis of niacin from tryptophan in the rat and other animals. Studies with Neurospora and mammals have demonstrated that the pathway from tryptophan goes through k...
متن کامل3-hydroxyanthranilic Acid Metabolism
The participation of 3-hydroxyanthranilic acid as an intermediate in the biosynthesis of nicotinic acid from tryptophan was first demonstrated in certain mutant strains of Neurospora in 1948 by Bonner (1) and by Mitchell and Nyc (2). In addition, Mitchell et al. (3) found that 3-hydroxyanthranilic acid can replace nicotinic acid in the nutrition of the rat. In 1946 Singal et al. (4) noted a sub...
متن کاملStudies on the Metabolism of the Benzene Ring of Tryptophan in Mammalian Tissues. I. Enzymic Formation of Glutaric Acid from 3-hydroxyanthranilic Acid.
Hankes and Henderson (I), Gholson et al. (2), and Gholson and Henderson (3) demonstrated that nL-tryptophan-7cu-14C was metabolized by the rat to r4C02 via acetate-1-r4C. Subsequently, Gholson et al. (4) indicated that 3-hydroxyanthranilic acid was an intermediate in the major pathway for the degradation of the benzene ring of tryptophan. Further experiments in viva have provided evidence that ...
متن کاملOrgan Correlation with Tryptophan Metabolism Obtained by Analyses of TDO-KO and QPRT-KO Mice
The aim of this article is to report the organ-specific correlation with tryptophan (Trp) metabolism obtained by analyses of tryptophan 2,3-dioxygenase knockout (TDO-KO) and quinolinic acid phosphoribosyltransferase knockout (QPRT-KO) mice models. We found that TDO-KO mice could biosynthesize the necessary amount of nicotinamide (Nam) from Trp, resulting in the production of key intermediate, 3...
متن کاملQuinolinic Acid Metabolism
Since the observation (1) that tryptophan and nicotinic acid are mutually interchangeable, within limits, in supporting the growth of rats, considerable evidence has accumulated which indicates that biosynthesis of nicotinic acid can proceed from tryptophan (2-5). Unequivocal evidence for this transformation was provided by the experiments of Heidelberger et al. (6) who fed labeled tryptophan @...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 62 1 شماره
صفحات -
تاریخ انتشار 1956